Strand-preferred base editing of organellar and nuclear genomes using CyDENT

AI-assisted structural predictions and alignments establishes a new protein classification and functional mining method, further discovering a suite of single- and double-stranded deaminases, which show great potential as bespoke base editors for therapeutic or agricultural breeding applications

PrimeRoot editors employ optimized prime editing guide RNA designs, an enhanced plant prime editor and superior recombinases to enable precise large DNA insertions of up to 11.1 kilobases into plant genomes

By using base editing or prime editing to generate de novo uORFs or to extend existing uORFs by mutating their stop codons, we generated a suite of uORFs that incrementally downregulate the translation of primary open reading frames (pORFs) to 2.5–84.9% of the wild-type level

Plant prime editing efficiencies can be enhanced through protein engineering

Multiplex genome editing breeds disease resistant and high-yielding wheat in one generation

High-throughput genome editing screens facilitates new gene discovery

Using base editing to create transgene-free herbicide resistant crops

Development of a rapid and comprehensive method to evaluate base editing off-target mutations

Multiplex genome editing enables rapid domestication of wild crop species